BOTOX Injections for Migraines

Although known primarily as a treatment for facial frown lines and "crow's feet," BOTOX Cosmetic, which is made from a type of bacteria known as Clostridium botulinum type A, also helps, according to the American Headache Society, to reduce the severity and frequency of migraine headaches. Migraines are often caused by reactions to certain triggers that stimulate the production of neurotransmitters in nerve cells, producing pain and other debilitating symptoms.

BOTOX injections are believed to work by either reducing muscle contractions or blocking pain-transmitting chemicals, or by a combination of the two. Patients typically receive BOTOX injections every 3 months; benefits are usually seen by the second treatment. Eventually, some patients are able to extend the time between treatments by up to 6 months.

Candidates for BOTOX Injections for Migraines

BOTOX injections have received United States Food and Drug Administration approval for treating migraines in adults at least 18 years old who have been diagnosed with chronic migraines. In clinical studies, BOTOX injections were shown to be a safe and effective treatment for those who have 15 or more days of headaches each month, and whose headaches last for at least 4 hours. BOTOX treatment reduced the number of days that study participants experienced headaches by as many as 9 days a month (compared to those who took a placebo). Migraines that do develop are often less severe than those experienced prior to BOTOX treatment.

BOTOX injections may be a successful treatment for chronic migraine sufferers whose headaches have not responded well to, or who have experienced rebound headaches from, other migraine medications. Studies have not yet confirmed whether BOTOX Cosmetic is an effective form of treatment for episodic migraines, which occur 14 or fewer days per month.

BOTOX-Injection Procedure

BOTOX injections are given in a doctor's office. Premeasured amounts of BOTOX Cosmetic are injected in several precise locations around the patient's head and neck. Locations generally include the forehead; the left and right sides of the head (above the ears); the back of the head; the base of the head (just above the neck); and down the sides of the neck. A total of 31 injections is made in those seven areas during a treatment session. For most patients, injections are not painful, producing only slight discomfort similar to that from pinpricks.

Side Effects of BOTOX Injections for Migraines

BOTOX Cosmetic is considered a safe form of treatment when given by a physician in the approved manner and at the recommended dosage. There is the potential for side effects, however, some of which include:

  • Temporary neck pain
  • Muscle weakness
  • Injection-site bruising

Less common side effects of injecting BOTOX Cosmetic to treat muscle spasms include:

  • Headache
  • Stiffness
  • Pain
  • Muscle spasms
  • Slight facial paralysis

Rare, but more serious, complications include difficulty swallowing, breathing or speaking. If these symptoms occur at any time from the day BOTOX Cosmetic is injected to several weeks afterward, immediate medical attention is required.

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